She was great in The Fugitive; I mean especially it was a great show, Stephen King called it the greatest TV show of all time. David Janssen was voted the greatest leading man in television of all time, he was kinda the male counterpart to Mary Tyler Moore. Cool that she played Karen's mom in Will and Grace.

I see a rivaling string of TV shows between the Lorre crew and Kohan/Mutchnick in the 90s, later 80s and 2000s; and Cybill, Spin City, a bit Defenders of the Earth (Lorre started with Comics), Two and a Half Men, somewhat Lost, a little bit the Fugitive reboot, and maybe MacGyver et. al. on the one hand and on the other Will and Grace, Frasier, Cheers, and I guess Golden Girls (Kohan/Mutchnick I think met at the Golden Girls, Marc Cherry started-ish(?) there as well), somewhat Desperate Housewives, ER, a little bit Alf (e.g. Max Wright played a progressive, left wing politician in a two-part episode on Cheers and was a very accomplished theatre actor, as several others at least somewhat in that line-up string). Wright also had a starring role in Reds, which was the mainish project of Warren Beatty's life, Beatty's wife Annett Bening was the female lead in The American President with Michael Douglas, which also starred John Mahoney and Wendy Malick, both as members of the White House staff, who would later be reunited in Frasier, playing a couple. The movie was written by Aaron Sorkin, who had a short affair with Kristin Davis, who had a complementary role to Grace in an episode of W&G.

Michael J Fox's role was inspired by George Stephanopolous and would help him get the lead in Spin City afterwards, as did Martin Sheen's role with The West Wing, which connects The West Wing with TAAHM and the Lorre Wing, but I guess it is closer to the W&G, Cheers, Frasier, DH wing. Adrian Lester's role in Primary Colors was also inspired by Stephanopolous, and it had Emma Thompson as Hillary Clinton, who had played Frasier's first wife in Cheers, and Maura Tierney in a main role as well, who was an integral part on ER, which I guess is a bit connected to the W&G, Cheers, ... wing, and had the husband of Felicity Huffman in it, who also had a small role in Frasier, besides DH main role. The movie also had Diane Ladd in it, whose husband, Bruce Dern, had memorable roles as villain in The Fugitive, which connects Primary Colors more with the Lorre wing, one next to his wife. Alison Janney had a role in it as well, and she played a small but important role in Lost.

I see the Mary Tyler Moore Show, Cheers and Frasier as a trilogy, and I Love Lucy and W&G as Alpha and Omega, also great that they had a reminiscence episode of I Love Lucy in the second last episode of W&G. I regard The Mary Tyler Moore Show and The Fugitive as integral parts of the different strings, and somewhat complementary to each other, also their leads and The Honeymooners as something like an ILL complementary, antagonistic Alpha leading to the Lorre string. David Paymer was in The American President, a few episodes of Cheers and in Nixon, as was David Hyde Pierce. Nixon was played by Anthony Hopkins, e.g. called the greatest actor alive about 13 years ago by Hugh Grant in an interview, who called it the best thing he's ever done, who played Hitchcock a few years ago. Roz Doyle's mom in Frasier was played by Eva Marie Saint, one of the last surviving members of the Golden Age of Hollywood. Fellow North by Northwest costar Philip Ober was third husband to Vivian Vance.